Thursday, March 2, 2017

Ligand and Target Discovery by Fragment-Based Screening in Human Cells

Christopher G. Parker, Andrea Galmozzi, Yujia Wang, Bruno E. Correia, Kenji Sasaki, Christopher M. Joslyn, Arthur S. Kim, Cullen L. Cavallaro, R. Michael Lawrence, Stephen R. Johnson, Iñigo Narvaiza, Enrique Saez, Enrique Saez,Enrique Saez, Benjamin F. Cravatt6, Benjamin F. Cravatt

DOI: 10.1016/j.cell.2016.12.029
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Fragment-Based Covalent Targeting of Lysines at the Allosteric Latch Site of SHP2.

  Vincenzo Di Lorenzo , Noémi Csorba , Renáta Szabó , Levente Kollár , Yvette Roske , Ivan Rand̵elović , Krisztina Balázs , Tibor Vikt...