Tuesday, April 11, 2017

Chemistry World: Drugs, the permanent way

Exceptions to a long-held rule against chemically bonding to biological targets are powering new cancer medicines, finds Andy Extance

 https://www.chemistryworld.com/feature/covalent-inhibitor-drugs/2500494.article
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Overcoming EGFR Resistance by Monovalent and Bident Inhibitors Targeting Cys775

  Zhengnian Li , Jie Jiang , Yaning Wang , Scott B. Ficarro , Stephen J. Collins , Tyler S. Beyett , Ilse K. Schaeffner , Isidoro Tavares , ...