Tuesday, April 11, 2017

Chemistry World: Drugs, the permanent way

Exceptions to a long-held rule against chemically bonding to biological targets are powering new cancer medicines, finds Andy Extance

https://www.chemistryworld.com/feature/covalent-inhibitor-drugs/2500494.article

Structure-Guided Optimization of 4-Chloro-Pyrazolopyridine Analogs for Covalent PREP Inhibition

Kalyani Thakur, Ian Fucci, Joshua Pandian, Kiall F. Suazo, Diana C. F. Monteiro, and Euna Yoo Journal of Medicinal Chemistry 2025 DOI: 10.1...