Dattatraya Gautam Rawale, Kalyani Thakur, Pranav Sreekumar, Sajeev T. K., Ramesh A, Srinivasa Rao Adusumalli, Ram Kumar Mishra and Vishal Rai
Chemical Science, 2021
The conservation of chemoselectivity becomes invalid for multiple electrophilic warheads during protein bioconjugation. Consequently, it leads to unpredictable heterogeneous labeling of proteins. Here, we report that a linchpin can create a unique chemical space to render site-selectivity for histidine and aspartic acid modification overcoming the pre-requisite of chemoselectivity.