Dattatraya Gautam Rawale, Kalyani Thakur, Pranav Sreekumar, Sajeev T. K., Ramesh A, Srinivasa Rao Adusumalli, Ram Kumar Mishra and Vishal Rai
Chemical Science, 2021
https://doi.org/10.1039/D1SC00335F
The conservation of chemoselectivity becomes invalid for multiple electrophilic warheads during protein bioconjugation. Consequently, it leads to unpredictable heterogeneous labeling of proteins. Here, we report that a linchpin can create a unique chemical space to render site-selectivity for histidine and aspartic acid modification overcoming the pre-requisite of chemoselectivity.
