Ostrem, J.M.L., Peters, U. & Shokat, K.M
Nat Chem Biol (2024).
https://doi.org/10.1038/s41589-024-01691-5
RAS proteins, central drivers of cancer, appeared ‘undruggable’ for almost 30 years. Here we provide a personal perspective on the effort leading to our initial report of KRASG12C inhibitors in 2013, and the decade of discoveries that followed.
Direct RAS inhibitors turn 10
