Xingyu Ma, Manyi Xu, Fengge Wang, Tingting Hu, Xinyuan Chena and Chong-Jing Zhang
Chem. Commun., 2024Reversible covalent electrophiles with the advantages of both reversible and covalent interactions receive much attention in the fields of chemical biology and medicinal chemistry. Here, we report two electron-deficient olefins activated by amide and ester, amide-substituted acrylamide and methyl ester-substituted acrylamide, targeting thiols in a reversible covalent manner.
