Saturday, September 17, 2016

Covalent inhibitors that target lysine side chains

Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain

Gizem Akçay, Matthew A Belmonte, Brian Aquila, Claudio Chuaqui, Alexander W Hird, Michelle L Lamb, Philip B Rawlins, Nancy Su, Sharon Tentarelli, Neil P Grimster & Qibin Su

Nature Chemical Biology (2016) doi:10.1038/nchembio.2174

Characterization of F-30 as an FGFR2/4-selective covalent inhibitor with activity against clinically relevant mutations

Lin Zhang, Xueru Liu, Wuqing Deng, Tanyuxuan Yang, Ke Gui, Yuepiao Cai, Yongheng Chen, Xiaojuan Chen, Biochemical Pharmacology , 2026 , 1185...