Monday, September 5, 2016

Cysteinome: The first comprehensive database for proteins with targetable cysteine and their covalent inhibitors

Cysteinome: The first comprehensive database for proteins with targetable cysteine and their covalent inhibitors

  • a Center for Molecular Medicine, School of Life Science and Biotechnology, Dalian University of Technology, Dalian, 116023, PR China
  • b School of Pharmacology, Dalian University of Technology, Dalian, 116023, PR China
doi: 10.1016/j.bbrc.2016.08.109

http://www.cysteinome.org/

Dual-Site Covalent Targeting Enables BD2-Selective BET Inhibition With Potent Antitumor Activity in Mice

Jibo Kang, Xuan Wang, Hong Zhang, Jieying Lin, Peng Chen, Zuqin Wang, Zengjun Hao, Fengfei Miao, Fengcai Zhang, Tao Li, Yusheng Xie, Junjian...