Monday, September 5, 2016

Cysteinome: The first comprehensive database for proteins with targetable cysteine and their covalent inhibitors

Cysteinome: The first comprehensive database for proteins with targetable cysteine and their covalent inhibitors

  • a Center for Molecular Medicine, School of Life Science and Biotechnology, Dalian University of Technology, Dalian, 116023, PR China
  • b School of Pharmacology, Dalian University of Technology, Dalian, 116023, PR China
doi: 10.1016/j.bbrc.2016.08.109

http://www.cysteinome.org/

A covalent inhibitor targeting Cys-349 of LIMK1 confers selectivity over LIMK2

Jon B. Patteson,  Ioannis Manolaridis, Mee Ra Hong,  Jennifer M. Johnston, Samaneh Mesbahi-Vasey,  Michael C. Gregory ,Daniel V. Iwamoto Joh...