Tuesday, June 27, 2017

Residue-Specific Peptide Modification: A Chemist’s Guide

Justine N. deGruyter, Lara R. Malins, and Phil S. Baran

Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037

DOI: 10.1021/acs.biochem.7b00536

Advances in bioconjugation and native protein modification are appearing at a blistering pace, making it increasingly time consuming for practitioners to identify the best chemical method to modify a specific amino acid residue in a complex setting. The purpose of this perspective is to provide an informative, graphically-rich manual highlighting significant advances in the field over the past decade. This guide will help triage candidate methods for peptide alteration, and will serve as a starting point for those seeking to solve longstanding challenges.

Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders

Nathanael Schiander Gray ,  Zhe Zhuang ,  Woong Sub Byun ,  Zuzanna Kozicka ,  Katherine Donovan ,  Brendan Dwyer ,  Abby Thornhill ,  Hanna...