Justine N. deGruyter, Lara R. Malins, and Phil S. Baran
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037
DOI: 10.1021/acs.biochem.7b00536
Advances in bioconjugation and native
protein modification are appearing at a blistering pace,
making it increasingly time consuming for practitioners
to identify the best chemical method to modify a specific
amino acid residue in a complex setting. The purpose of
this perspective is to provide an informative, graphically-rich
manual highlighting significant advances in the
field over the past decade. This guide will help triage
candidate methods for peptide alteration, and will serve
as a starting point for those seeking to solve longstanding
challenges.
-
Design, synthesis and biological evaluation of the activity-based probes for FGFR covalent inhibitorDandan Zhu, Zijian Zheng, Huixin Huang, Xiaojuan Chen, Shuhong Zhang, Zhuchu Chen, Ting Liu, Guangyu Xu, Ying Fu, Yongheng Chen, European Jo...
-
DOI Ansgar Oberheide, Maxime van den Oetelaar, Jakob Scheele, Jan Borggräfe, Semmy Engelen, Michael Sattler, Christian Ottmann, ...
-
Nafizul Haque Kazi, Nikolas Klink, Kai Gallant, Gian-Marvin Kipka & Malte Gersch Nat Struct Mol Biol , 2025 https://doi.org/10.1038/s415...
