Sunday, January 16, 2022

A Series of Pyrazole Analogs Binding to KRASG12C as Potential Cancer Treatment

Gerard Rosse

ACS Med. Chem. Lett. 2022, 13, 1, 11–12

The compounds of this patent application represent a potential treatment for cancer characterized by KRAS, HRAS, and NRAS GC12 mutation. The compounds have the ability to inhibit the G12C mutant of KRAS, HRAS, and NRAS via the formation of an irreversible bond to cysteine 12. The irreversible binding locks KRAS in an inactivate state and disrupts downstream signaling.

Covalent drug discovery using sulfur(VI) fluoride exchange warheads

Huang Huang, Lyn H. Jones Expert Opinion on Drug Discovery , 2023 Covalent drug discovery has ...