Thursday, January 19, 2017

Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes

Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes

Qian Zhao†‡⊥, Xiaohu Ouyang†⊥, Xiaobo Wan†, Ketan S. Gajiwala∥, John C. Kath∥, Lyn H. Jones§, Alma L. Burlingame‡, and Jack Taunton*†
†Department of Cellular and Molecular Pharmacology and ‡Pharmaceutical Chemistry, University of California, San Francisco, California 94158, United States
§ Medicine Design, Pfizer, Cambridge, Massachusetts 02139, United States
∥ Worldwide Research and Development, Pfizer, San Diego, California 92121, United States
J. Am. Chem. Soc., 2017, 139 (2), pp 680–685
DOI: 10.1021/jacs.6b08536
Publication Date (Web): January 4, 2017
Copyright © 2017 American Chemical Society

Oncogenic KRAS G12C: Kinetic and Redox Characterization of Covalent Inhibition

Minh V. Huynh, Derek Parsonage, Tom E. Forshaw, Venkat R. Chirasani, G. Aaron Hobbs, Hanzhi Wu, Jingyun Lee, Cristina M. Furdui, Leslie B. P...