A blog highlighting recent publications in the area of covalent modification of proteins, particularly relating to covalent-modifier drugs. @CovalentMod on Twitter, @covalentmod@mstdn.science on Mastodon, and @covalentmod.bsky.social on BlueSky
A covalent PFKL activator suppresses tumor growth
Jiang, X.; Lynch, E. M.; Lyu, C.; Wilson, C. N.; Salay, L. E.; Hess, H. T.; Lyons, S. N.; Lu, M.-J.; Luo, S.; Kim, G.; Chan, H.-R.; Wolfe, W...
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Design, synthesis and biological evaluation of the activity-based probes for FGFR covalent inhibitorDandan Zhu, Zijian Zheng, Huixin Huang, Xiaojuan Chen, Shuhong Zhang, Zhuchu Chen, Ting Liu, Guangyu Xu, Ying Fu, Yongheng Chen, European Jo...
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L. Mader and J. W. Keillor, RSC Med. Chem ., 2025 DOI: 10.1039/D5MD00050E Potent reversible covalent inhibitors are often slow in establish...
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Yoav Shamir, Nir London bioRxiv 2025.03.19.642201 doi: https://doi.org/10.1101/2025.03.19.642201 Recent years have seen an explosion in the...