Wednesday, August 24, 2016

Angewante Chemie Review: Targeted Covalent Inhibitors for Drug Design by Thomas Baille

Targeted Covalent Inhibitors for Drug Design

The current issue of Angewante Chemie includes and extensive review on pharmaceutical inhibitors by Prof. T. A. Baillie from the Department of Medicinal Chemistry at the University of Washington.

DOI: 10.1002/anie.201601091
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A covalent irreversible inhibitor binds in two mutually exclusive conformations to the active-site cysteine residue of human aldehyde dehydrogenase 1A3

Daniela Covaleda, David Vizarraga, Tulsi Upadhyay, Jiyun Zhu, Daniel Abegg, Raquel Pequerul, Martín Hugo, Alexander Adibekian, Ignacio Fita,...