Thursday, January 19, 2017

Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes

Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes

Qian Zhao†‡⊥, Xiaohu Ouyang†⊥, Xiaobo Wan†, Ketan S. Gajiwala∥, John C. Kath∥, Lyn H. Jones§, Alma L. Burlingame‡, and Jack Taunton*†
†Department of Cellular and Molecular Pharmacology and ‡Pharmaceutical Chemistry, University of California, San Francisco, California 94158, United States
§ Medicine Design, Pfizer, Cambridge, Massachusetts 02139, United States
∥ Worldwide Research and Development, Pfizer, San Diego, California 92121, United States
J. Am. Chem. Soc., 2017, 139 (2), pp 680–685
DOI: 10.1021/jacs.6b08536
Publication Date (Web): January 4, 2017
Copyright © 2017 American Chemical Society

Covalent Modulators of the Vacuolar ATPase

Covalent Modulators of the Vacuolar ATPase

Ying-Chu Chen, Keriann M. Backus, Maria Merkulova, Christina Yang, Dennis Brown, Benjamin F. Cravatt, and Chao Zhang
J. Am. Chem. Soc.2017139 (2), pp 639–642

Thursday, January 5, 2017

What Do Reactive Fragments Actually Do in Cells?

What Do Reactive Fragments Actually Do in Cells?
Angewante Chemie
Prof. Dr. Oliver Plettenburg
DOI: 10.1002/anie.201607914

Thiol Reactivity of N-Aryl α-Methylene-γ-lactams: Influence of the Guaianolide Structure [@KayBrummond]

 Daniel P. Dempe, Chong-Lei Ji, Peng Liu, and Kay M. Brummond The Journal of Organic Chemistry, 2020 DOI: 10.1021/acs.joc.2c01530 The α-meth...