Tuesday, April 11, 2017

Chemistry World: Drugs, the permanent way

Exceptions to a long-held rule against chemically bonding to biological targets are powering new cancer medicines, finds Andy Extance

 https://www.chemistryworld.com/feature/covalent-inhibitor-drugs/2500494.article
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An enantioselective covalent inhibitor of BAX confers cytoprotection in vivo

Peiwen Shi, Bruno Melillo, Matthew W. McHenry, Christina M. Camara, Ka Yang, Evert Njomen, Marina Godes, Maria F. Pazyra-Murphy, Mary Rose B...