Saturday, September 17, 2016

Covalent inhibitors that target lysine side chains

Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain

Gizem Akçay, Matthew A Belmonte, Brian Aquila, Claudio Chuaqui, Alexander W Hird, Michelle L Lamb, Philip B Rawlins, Nancy Su, Sharon Tentarelli, Neil P Grimster & Qibin Su

Nature Chemical Biology (2016) doi:10.1038/nchembio.2174

State-of-the-art covalent virtual screening with AlphaFold3

Yoav Shamir, Nir London bioRxiv 2025.03.19.642201; doi: https://doi.org/10.1101/2025.03.19.642201 Recent years have seen an explosion in the...