Thursday, March 2, 2017

Ligand and Target Discovery by Fragment-Based Screening in Human Cells

Christopher G. Parker, Andrea Galmozzi, Yujia Wang, Bruno E. Correia, Kenji Sasaki, Christopher M. Joslyn, Arthur S. Kim, Cullen L. Cavallaro, R. Michael Lawrence, Stephen R. Johnson, Iñigo Narvaiza, Enrique Saez, Enrique Saez,Enrique Saez, Benjamin F. Cravatt6, Benjamin F. Cravatt

DOI: 10.1016/j.cell.2016.12.029
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A covalent PFKL activator suppresses tumor growth

Jiang, X.; Lynch, E. M.; Lyu, C.; Wilson, C. N.; Salay, L. E.; Hess, H. T.; Lyons, S. N.; Lu, M.-J.; Luo, S.; Kim, G.; Chan, H.-R.; Wolfe, W...