Tuesday, April 11, 2017

Chemistry World: Drugs, the permanent way

Exceptions to a long-held rule against chemically bonding to biological targets are powering new cancer medicines, finds Andy Extance

https://www.chemistryworld.com/feature/covalent-inhibitor-drugs/2500494.article

Advancing Covalent Ligand and Drug Discovery beyond Cysteine

Gibae Kim, R. Justin Grams, and Ku-Lung Hsu Chemical Reviews   2025 DOI: 10.1021/acs.chemrev.5c00001 Targeting intractable proteins remains ...