Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes

Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes

Qian Zhao†‡⊥, Xiaohu Ouyang†⊥, Xiaobo Wan†, Ketan S. Gajiwala∥, John C. Kath∥, Lyn H. Jones§, Alma L. Burlingame‡, and Jack Taunton*†
†Department of Cellular and Molecular Pharmacology and ‡Pharmaceutical Chemistry, University of California, San Francisco, California 94158, United States
§ Medicine Design, Pfizer, Cambridge, Massachusetts 02139, United States
∥ Worldwide Research and Development, Pfizer, San Diego, California 92121, United States
J. Am. Chem. Soc., 2017, 139 (2), pp 680–685
DOI: 10.1021/jacs.6b08536
Publication Date (Web): January 4, 2017
Copyright © 2017 American Chemical Society

Covalent Modulators of the Vacuolar ATPase

Ying-Chu Chen, Keriann M. Backus, Maria Merkulova, Christina Yang, Dennis Brown, Benjamin F. Cravatt, and Chao Zhang

J. Am. Chem. Soc., 2017, 139 (2), pp 639–642

DOI: 10.1021/jacs.6b12511

What Do Reactive Fragments Actually Do in Cells?

What Do Reactive Fragments Actually Do in Cells?
Angewante Chemie
Prof. Dr. Oliver Plettenburg
DOI: 10.1002/anie.201607914