Thursday, January 19, 2017

Covalent Modulators of the Vacuolar ATPase

Covalent Modulators of the Vacuolar ATPase

Ying-Chu Chen, Keriann M. Backus, Maria Merkulova, Christina Yang, Dennis Brown, Benjamin F. Cravatt, and Chao Zhang
J. Am. Chem. Soc., 2017, 139 (2), pp 639–642

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Discovery and development of Krazati (adagrasib/MRTX849), a potent, selective, orally bioavailable, covalent KRASG12C(OFF) inhibitor

Adrian L. Gill, Mathew A. Marx RAS Drug Discovery Past, Present and Future 2025 , 205-227 https://doi.org/10.1016/B978-0-443-21861-3.00017-...