Justine N. deGruyter, Lara R. Malins, and Phil S. Baran
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037
DOI: 10.1021/acs.biochem.7b00536
Advances in bioconjugation and native
protein modification are appearing at a blistering pace,
making it increasingly time consuming for practitioners
to identify the best chemical method to modify a specific
amino acid residue in a complex setting. The purpose of
this perspective is to provide an informative, graphically-rich
manual highlighting significant advances in the
field over the past decade. This guide will help triage
candidate methods for peptide alteration, and will serve
as a starting point for those seeking to solve longstanding
challenges.
