Huang Huang, Lyn H. Jones
Expert Opinion on Drug Discovery, 2023
https://doi.org/10.1080/17460441.2023.2218642
- Covalent drug discovery has traditionally focused on targeting cysteine, but the amino acid is often absent in protein binding sites. This review makes the case to move beyond cysteine labeling using sulfur (VI) fluoride exchange (SuFEx) chemistry to expand the druggable proteome.
